Research and Development

Microbide prides itself in our R&D

At the core of Microbide Limited’s product focus is our commitment to extend the knowledge-base in relation to pathogen elimination, and further our understanding of microbial control in a variety of applications to address unmet needs with world-class solutions.

The aldehydes, as a chemical class, make excellent agents to kill microbial pathogens and disrupt biofilms. No other class of chemicals offers the possibility of complete decontamination of microbial flora of all kinds (bacteria, fungi, spores, and viruses).

The problem, until now, has been the ability to harness this capability before the aldehyde dissipates. Microbide Limited stabilizes aldehydes in solution using a patented process so that the aldehyde solutions may be used at neutral pH to provide exceptional deactivation of microbes. Microbide’s stabilized aldehydes are pre-activated for exceptional biocidal capacity; and used for many applications as liquids, aerosols, creams, foams, gels and semi solids, as well as wipes.

Aldehydes and their Mode of Action

Aldehydes are organic compounds containing a carbonyl group, ( -CHO) a carbon double bonded to oxygen bonded to hydrogen and another group. By definition, the aldehyde carbonyl group must always lie at the end of a carbon chain in order to provide both the –OH and –H components of the carbonyl. The C=O bond is highly polar. Aldehydes exist as mono- and di- aldehydes, having one or two reactive moieties respectively.

Aldehydes are widespread in nature, and are derived from both plants and animals. These are frequently used as flavors and fragrances. Many of the di-aldehydes are derived from petrochemicals. All of the aldehydes are chiral compounds and exist in both levo- and dextro- rotatory forms.

Aldehydes are used for many purposes, either as starting ingredients for other chemicals or for their own capabilities.  At Microbide use the aldehydes having between 2 and 12 carbons for their antimicrobial capability. The aldehydes are very reactive. They may be reduced to a primary alcohol, or oxidized to the corresponding organic acid. In the presence of an opportunistic nitrogen, an aldehyde will bind to the nitrogen containing compound or protein on a bacterial cell wall and cause rupture of the membrane, with loss of permeability and coagulation of the cytoplasm.

Biocidal capacity of aldehydes depends on the environment in which it is used, particularly: the target organism or microbial ecosystem, the concentration, contact time, pH and temperature. Unlike antibiotics, because the method of lethality to microbes is non-specific, it is much more difficult for germs to evade the killing power of these disinfectants.

Complexed Aldehydes

In order to harness the biocidal capacity of various aldehydes, Microbide uses a patented process to “complex” the active aldehyde ingredient with a number of inactive ingredients to hold the aldehyde in solution and reduce its volatility. By associating various aldehydes with surfactants and other biodegradable ingredients, the aldehyde is protected by its association in micellular structures. The micelles directionally point the active carbonyl group of the aldehyde toward the surface of the solution; thereby making the aldehyde biocide far more effective at killing germs.

Most of the product range is biodegradable. In general most aldehydes with ring structures (for example ortho phthalaldehyde) are not readily biodegradable.

Microbide’s solutions are developed at neutral pH for each active aldehyde ingredient. There is no requirement for activation prior to use.

Head-to-head comparative studies of Microbide’s complexed aldehydes versus their non-complexed market leading counterparts demonstrate significant improvement in efficacy, together with a reduced volatility profile and improved safety.

Microbide are developing a series of both complexed mon- and complexed di- aldehydes and combination products to address specific microbial control issues.